CBD Entourage Effect – Is “Team Hemp” a Thing?

CBD Entourage Effect – Is “Team Hemp” a Thing?

CBD Entourage Effect – Do Hemp’s Compounds Work as a Team?


Should your CBD vape give you the entourage effect?

Don’t be alarmed, it has nothing to do with getting high.

We’re just wondering if it’s something you should consider when you are looking for CBD vape juice or a CBD vape pen.

Let me explain.

If you start to read about CBD and hemp, you will undoubtedly hear about the CBD “entourage effect”.

It’s a very popular talking point. People in the CBD business love to throw the term around. But is it real? Does it matter?

The CBD Entourage Effect Concept

cannabis trichomes
Look at all that glorious goo. Let’s vape it!

Hemp produces CBD.

Additionally It produces over 400 phytochemicals (plant compounds) – cannabinoids, terpenes, flavinoids, fatty acids, etc.

The CBD entourage effect concept goes like this:

All of these plant goodies work in together to create a synergistic outcome that is greater than the sum of its parts. 

The team amplify and compliment each other and storm the endocannabinoid system – carrying CBD on their shoulders to victory.

It’s a theory that feels right –  intuitively.

It’s the idea that we should vape the “whole plant” for maximum potency.

I mean – why would hemp make all this other stuff if CBD is all you need?  Nature doesn’t waste anything. And it certainly packed  a lot of stuff in cannabis sativa.

We all really, really love the “whole plant” theory. It’s quite romantic. (Ever read Yew Trees?)

But is it true?

CBD Entourage Effect Research

Thanks to the idiotic and tragic prohibition on cannabis research in the US, Israel was about the only country in the world doing research on cannabis.

Cannabis research pioneer raphael mechoulam
Cannabis Research Pioneer, Raphael Mechoulam

In the 1960’s Professor Raphael Mechoulam was the first to isolate CBD and THC.

In 1998, Mechoulam co-wrote a paper introducing the phrase “entourage effect” for the first time. He noticed what seemed to be a synergistic result of multiple cannabinoids and terpenes working together.

That was over 20 years ago. The theory is more popular than ever,  but  no studies have been able to back it up.

We know that certain terpenes and cannabinoids have beneficial properties. But whether the work together or overlap each other is still unclear.

What We Do Know About the CBD Entourage Effect

Nevertheless, one thing is pretty clear. THC and CBD work together as a power couple.

We know that CBD balances out the strong psychoactive side effects of THC.

On the other hand, THC hits the brain in a way that CBD doesn’t.

Between the two of them, they lock into CB2 and CB1  receptors. They  combine to make a powerful medicine for pain and seizures – as evidenced by real and effective drugs.

The British company, GW Pharmaceuticals, make Sativex, a pain medicine for people with MS. It has a 1:1 ratio of THC/CBD.

And of course, there’s the legendary Charlotte’s Web anti-seizure formula which was a 30:1  CBD/THC.

Consequently, we know for a fact that THC and CBD have a real, proven 1-2 punch. 

But that’s a duo – not an entourage.

What About the Rest of the Gang?

Hemp flower with pineapple terpenes and the cbd entourage effect

So, what about all the other 400 hempy chemicals? Do they do boost CBD’s effect? Do they do their own thing, or are they irrelevant?

Well, the truth is… we don’t know – yet.

Furthermore, what if you don’t live in a legal cannabis state and your CBD vape has less than .3% THC? Does a 100/1  CBD/THC ratio still do anything?

Probably not.

But it’s OK.

It’s actually good news in a way.

The CBD Show

For one thing – it means that CBD is the undisputed star of the show. If you want to make that a one-person show, it’s perfectly fine.

You can ignore all of the marketing terms like broad spectrum, full spectrum and whole plant. Buy the best quality CBD isolate vape and go to town.

This is especially good news if you are concerned about THC and drug tests.

CBD by itself is pretty awesome.


Is Full Spectrum CBD Meaningless?

CBD Distillate entourage effect
Full Spectrum CBD Distillate

Extracting CBD from hemp is a fairly straight forward process. Mash up the plant. Distill out the CBD. Sell the rest for hog feed.

Making a full spectrum extract – which maintains all (or most) of the goodies – is complicated and expensive. Consequently, the result is expensive. What’s the point if all you need is CBD?

Wait. Don’t give up.

Even though we don’t have any proof yet, there is still a strong case to be made for vaping CBD with some or all of the other stuff.

  1. The Entourage effect quite probably is really a thing. We will find out eventually. But wouldn’t you want to taking in all that good stuff in the meanwhile?
  2. The phytochemicals are still beneficial each in their own way.  Just because the other plant compounds may or may not magically work together doesn’t mean they are useless. We know terpenes and flavinoids are beneficial. And we’re pretty sure the other minor cannabinoids are as well. They’re all good as individuals or a team.
  3. Vaping full spectrum hemp extract or hemp flower is a more authentic cannabis experience. Cannabis really is amazing. If you really want to appreciate the glory of hemp, you should breath in all the pine and dankness and citrus that oozes out of it – not just vape a strawberry milkshake CBD e-juice.


hemp field

Cannabis is the most evocative plant ever grown. And advocates tend to attribute mystical powers to it.

However, In my opinion, it really doesn’t matter if the entourage effect is ever scientifically proven.

Hemp is an incredible plant. I’m not sure why we have to insist that its compounds work together like some highly choreographed dance troupe rather than individually.

On the other hand, there’s more than a poetic beauty to the concept of the entourage effect.

It’s a kind of Holy Grail that will drive researchers, growers and manufacturers to find that strain, that ratio, that mix that does work like an inspired team. 

It’s already happening. We are seeing strains that are high in some of the less well-known cannabinoids – THCV for example – that might very well prove to be part of CBD’s enourage.

So, until we know for sure, the entourage effect is a beautiful concept that you can participate in or ignore.  You can take full spectrum hemp extract or CBD isolate.

They are both really, really good.


Breath in the goodness of CBD

John Astrab



Neither Hemp nor its byproducts are considered medicine. They are not intended to treat any specific ailment. We can make no claims as such.

All information, content, and material of this blog post is for informational purposes only and not intended to serve as a substitute for the consultation, diagnosis, and/or medical treatment of a qualified physician or healthcare provider.

All healthcare decisions are yours and yours alone.

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